Last updated: August 2026
How to Get PrEP in South Dakota
You can start PrEP in South Dakota without ever sitting in a waiting room: online consult, the required HIV test, a prescription, and delivery in about a week. Here's the exact route, what it costs, and who prescribes in your state.
The short version for South Dakota
- Telehealth PrEP is fully available in South Dakota — consult, labs, and prescription all happen remotely.
- With insurance, PrEP is usually $0 including lab work; without it, generic Truvada is about $20–30/month.
- Timeline: consult today, labs within days, medication in hand in roughly a week.
The fastest route in South Dakota
The Practice doesn't prescribe in South Dakota yet, but these established telehealth services do, and the process is the same: online consult, HIV test, prescription, delivery.
MISTR — free PrEP & DoxyPEP online, most states Wisp — sexual-health telehealth & pharmacy CallonDoc — same-day online prescriptions
What PrEP costs in South Dakota
Under the ACA, PrEP is preventive care: most insurance plans — including many Medicaid plans — cover the medication, the HIV test, and the follow-up labs at $0 out of pocket. South Dakota has expanded Medicaid, so if you qualify, PrEP medication and the required HIV and kidney lab work are covered as preventive care with no cost-sharing. Most commercial insurance plans cover it at $0 the same way.
Paying cash? Generic Truvada (tenofovir DF/emtricitabine) is typically $20–30 per month at discount pharmacies, and Gilead's copay program covers most insured patients' remaining costs. The full breakdown is in PrEP costs & insurance.
Prefer to see someone in person in South Dakota?
Telehealth is the fastest option for most people, but in-person care makes sense if you want same-day labs, need help with insurance, or want Apretude, the every-other-month injection, which must be given in a clinic. To find a provider near you, use the HIV.gov services locator or search for "PrEP clinic" plus your city — county health departments and community health centers across South Dakota frequently offer PrEP at low or no cost.
If you may have been exposed in the last 72 hours
That's PEP, not PrEP, and it's time-critical — read where to get PEP or go to an urgent care or ER in South Dakota now.