Modern Sexual Health,
Explained by Clinicians

Plain-English, medically reviewed guides to PrEP and DoxyPEP — what they are, what they cost (usually nothing), and how to get them without leaving home.

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The two tools, in one sentence each

PrEP is medication taken before possible exposure that prevents HIV with about 99% effectiveness. DoxyPEP is a single antibiotic dose taken after sex that sharply cuts syphilis, chlamydia, and gonorrhea. Together they cover most of what's coverable in sexual health — and both can be prescribed by telehealth.

PrEP guides

Start hereWhat is PrEP?The plain-English guide to 99% HIV prevention MedicationTruvada & generic PrEPThe $20–30/month workhorse, explained MedicationDescovy for PrEPWho it's for — and who it isn't MedicationInjectable PrEPOne shot every two months, no daily pill StrategyOn-demand 2-1-1 dosingPrEP only when you need it MoneyCosts & insuranceWhy most people pay $0 — every path there SafetyPrEP side effectsThe honest guide, myth-free EvidenceHow effective is PrEP?Where "99%" comes from, with the caveats For youPrEP for gay menMatching the options to your life For youPrEP for womenWhat's different and what works UrgentPEP vs PrEPOne letter apart — completely different clocks Get careGet PrEP onlinePrescription, labs, and delivery from home

DoxyPEP guides

Start hereWhat is DoxyPEP?The after-sex pill that prevents bacterial STIs How-toDoxyPEP dosageExactly how and when to take it SafetyDoxyPEP side effectsCommon, rare, and avoidable Get careGet DoxyPEP onlineA prescription in your cabinet before you need it

Why trust this site

Every clinical page here is written for readers, not algorithms, and reviewed by licensed providers at The Practice, a veteran-owned medical clinic in Jacksonville, Florida. Pages carry the reviewer's name and a last-updated date, and we revise as guidance evolves. When the evidence has honest limitations — and in this field it sometimes does — we say so on the page.

See your options — pick your state

Where you live determines who can prescribe for you via telehealth.

Good news: our reviewing clinical team at The Practice serves your state directly by telehealth.

Book a telehealth visit with The Practice

Or call (904) 877-1100

The Practice doesn't prescribe in your state yet. These established telehealth services do:

MISTR — free PrEP & DoxyPEP online, most states Wisp — sexual-health telehealth & pharmacy CallonDoc — same-day online prescriptions
Medical disclaimer: This site is for education only and is not a substitute for professional medical advice, diagnosis, or treatment. Always talk to a licensed clinician about your situation. If you may have been exposed to HIV in the last 72 hours, seek PEP immediately — go to an urgent care or ER now. Information reviewed against CDC guidance current as of the date shown.